901260-40-0

901260-40-0 structure

Name: LpxH-IN-AZ1
Chemical Name: LpxH-IN-AZ1
CAS Number: 901260-40-0
Molecular Formula: C₂₁H₂₂F₃N₃O₃S
Molecular Weight: 453.48
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2020-04-18 09:13:31
Modify Date: 2024-01-10 14:22:57
LpxH-IN-AZ1, a sulfonyl piperazine compound, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. LpxH-IN-AZ1 is a potent inhibitor of Klebsiella pneumoniae LpxH with IC50 of 0.36 μM [1].

Name	LpxH-IN-AZ1

Description	LpxH-IN-AZ1, a sulfonyl piperazine compound, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. LpxH-IN-AZ1 is a potent inhibitor of Klebsiella pneumoniae LpxH with IC50 of 0.36 μM [1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	LpxH-IN-AZ1 displays IC50 values of 0.36 μM against K. pneumoniae LpxH and 0.14 μM against E. coli LpxH, respectively[1]. LpxH-IN-AZ1 (1 μM) inhibits 75% of the activity of K. pneumoniae LpxH and 83% of the activity of E. coli LpxH in the presence of 100 μM UDPDAGn[1].
References	[1]. Cho J, et al. Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics. Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4109-4116.

Molecular Formula	C₂₁H₂₂F₃N₃O₃S
Molecular Weight	453.48

Hazard Codes	Xi