1434515-70-4

1434515-70-4 structure

Name: UCSF924
Chemical Name: UCSF924
CAS Number: 1434515-70-4
Molecular Formula: C₂₀H₂₂N₂O₂
Molecular Weight: 322.40
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2020-01-23 17:41:51
Modify Date: 2024-01-10 06:32:55
UCSF924 is a potent and specific dopamine D4 receptor (DRD4) partial agonist with a EC50 of 4.2 nM. UCSF924 has a high-affinity with a Ki value of 3 nM for DRD4 and shows no measurable affinity for D2, D3 or the F261V/L328F D4 mutant. UCSF924 is a 7.4-fold bias toward arrestin over Gαi/o signaling, referenced to quinpirole[1].

Name	UCSF924

Description	UCSF924 is a potent and specific dopamine D4 receptor (DRD4) partial agonist with a EC50 of 4.2 nM. UCSF924 has a high-affinity with a Ki value of 3 nM for DRD4 and shows no measurable affinity for D2, D3 or the F261V/L328F D4 mutant. UCSF924 is a 7.4-fold bias toward arrestin over Gαi/o signaling, referenced to quinpirole[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor
Target	Ki: 3 nM (dopamine D4 receptor)[1]
References	[1]. Wang S, et al. D4 dopamine receptor high-resolution structures enable the discovery of selective agonists. Science. 2017 Oct 20;358(6361):381-386.

Molecular Formula	C₂₀H₂₂N₂O₂
Molecular Weight	322.40