1781934-47-1
1781934-47-1 structure
- Name: SNAP 94847 hydrochloride
- Chemical Name: SNAP 94847 hydrochloride
- CAS Number: 1781934-47-1
- Molecular Formula: C29H33ClF2N2O2
- Molecular Weight: 515.03
- Catalog: Signaling Pathways GPCR/G Protein MCHR1 (GPR24)
- Create Date: 2020-01-23 17:03:51
- Modify Date: 2024-01-03 21:19:07
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SNAP 94847 hydrochloride is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCHR1) antagonist with (Ki= 2.2 nM, Kd=530 pM), it displays >80-fold and >500-fold selectivity over MCHα1A and MCHD2 receptors respectively. SNAP 94847 hydrochloride binds with high affinity to the mouse and rat MCHR1 with minimal cross-reactivity to other GPCR, ion channels, enzymes, and transporters[1][3].
| Name | SNAP 94847 hydrochloride |
|---|
| Description | SNAP 94847 hydrochloride is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCHR1) antagonist with (Ki= 2.2 nM, Kd=530 pM), it displays >80-fold and >500-fold selectivity over MCHα1A and MCHD2 receptors respectively. SNAP 94847 hydrochloride binds with high affinity to the mouse and rat MCHR1 with minimal cross-reactivity to other GPCR, ion channels, enzymes, and transporters[1][3]. |
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| Related Catalog | |
| Target |
Ki: 2.2 nM (MCHR1); Kd: 530 pM (MCHR1)[3] |
| In Vivo | SNAP 94847 hydrochloride (oral gavage; 20 mg/kg; 14 days) shows an exaggerated locomotor response to acute quinpirole [treatment: F(2,19)=11.31, treatment × time: F(34,323) = 4.061], the effect of SNAP 94847 on quinpirole-evoked ambulations over the entire observation period is significant compared to the untreated animals[2]. SNAP 94847 hydrochloride (oral administration; 20 mg/kg; 21 days) in drink water, produces a significant increase in ambulation relative to untreated animals [treatment: F(3,28) = 8.971; treatment × time: F(51,476)=11.50]. shows a marked increase in locomotion is apparent after 40 min in the SNAP 94847-treated group,this effect is significant over 180 min[2]. SNAP 94847 hydrochloride (oral administration; 10 mg/kg), has a good bioavailability (59%), low plasma and blood clearances of 4.2 L/hr/kg and 3.3 L/hr/kg, respectively, and the half-life was shown to be 5.2 h in rats in a PK study[3]. Animal Model: Rat[2] Dosage: 20 mg/kg Administration: Oral administration; 20 mg/kg; 14 days Result: Exhibited a exaggerated locomotor response to acute quinpirole. Animal Model: Rat[2] Dosage: 10 mg/kg Administration: Oral administration; 10 mg/kg Result: Exhibited good physicochemical properties in rats. |
| References |
| Molecular Formula | C29H33ClF2N2O2 |
|---|---|
| Molecular Weight | 515.03 |