1399880-38-6

1399880-38-6 structure
1399880-38-6 structure
  • Name: (R)-Praziquantel D11
  • Chemical Name: (R)-Praziquantel D11
  • CAS Number: 1399880-38-6
  • Molecular Formula: C19H13D11N2O2
  • Molecular Weight: 323.47
  • Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
  • Create Date: 2020-01-23 13:39:51
  • Modify Date: 2024-01-22 10:37:48
  • (R)-Praziquantel D11 is the deuterium labeled (R)-Praziquantel. (R)-Praziquantel, the active enantiomer of Praziquantel, is a partial agonist of the human 5-HT2B receptor. (R)-Praziquantel acts as an antischistosomal eutomer[1].

Name (R)-Praziquantel D11
Description (R)-Praziquantel D11 is the deuterium labeled (R)-Praziquantel. (R)-Praziquantel, the active enantiomer of Praziquantel, is a partial agonist of the human 5-HT2B receptor. (R)-Praziquantel acts as an antischistosomal eutomer[1].
Related Catalog
Target

5-HT2B Receptor

Antischistosomal

In Vitro (R)-Praziquantel ((R)-PZQ) is a G-protein-coupled receptor ligand. (R)-Praziquantel modulation of serotoninergic signaling occurs over a concentration range sufficient to regulate vascular tone of the mesenteric blood vessels where the adult parasites reside within their host. The important anthelmintic is supported by a broad, cross species polypharmacology with (R)-Praziquantel modulating signaling events in both host and parasite[1].
References

[1]. Chan JD, et al. The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand. Nat Commun. 2017 Dec 5;8(1):1910.

Molecular Formula C19H13D11N2O2
Molecular Weight 323.47