1399880-38-6

1399880-38-6 structure

Name: (R)-Praziquantel D11
Chemical Name: (R)-Praziquantel D11
CAS Number: 1399880-38-6
Molecular Formula: C₁₉H₁₃D₁₁N₂O₂
Molecular Weight: 323.47
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2020-01-23 13:39:51
Modify Date: 2025-09-18 22:08:36
(R)-Praziquantel D11 is the deuterium labeled (R)-Praziquantel. (R)-Praziquantel, the active enantiomer of Praziquantel, is a partial agonist of the human 5-HT2B receptor. (R)-Praziquantel acts as an antischistosomal eutomer[1].

Name	(R)-Praziquantel D11

Description	(R)-Praziquantel D11 is the deuterium labeled (R)-Praziquantel. (R)-Praziquantel, the active enantiomer of Praziquantel, is a partial agonist of the human 5-HT2B receptor. (R)-Praziquantel acts as an antischistosomal eutomer[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT2B Receptor Antischistosomal
In Vitro	(R)-Praziquantel ((R)-PZQ) is a G-protein-coupled receptor ligand. (R)-Praziquantel modulation of serotoninergic signaling occurs over a concentration range sufficient to regulate vascular tone of the mesenteric blood vessels where the adult parasites reside within their host. The important anthelmintic is supported by a broad, cross species polypharmacology with (R)-Praziquantel modulating signaling events in both host and parasite[1].
References	[1]. Chan JD, et al. The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand. Nat Commun. 2017 Dec 5;8(1):1910.

Molecular Formula	C₁₉H₁₃D₁₁N₂O₂
Molecular Weight	323.47