1177279-49-0

1177279-49-0 structure

Name: Nebracetam hydrochloride
Chemical Name: Nebracetam hydrochloride
CAS Number: 1177279-49-0
Molecular Formula: C₁₂H₁₇ClN₂O
Molecular Weight: 240.73
Catalog: Signaling Pathways GPCR/G Protein mAChR
Create Date: 2020-01-23 15:37:51
Modify Date: 2024-01-11 17:44:33
Nebracetam hydrochloride, a nootropic M1-muscarinic agonist, induces a rise of intracellular Ca2+ concentration. Nebracetam hydrochloride exhibits an EC50 of 1.59 mM for elevating [Ca2+]i[1].

Name	Nebracetam hydrochloride

Description	Nebracetam hydrochloride, a nootropic M1-muscarinic agonist, induces a rise of intracellular Ca2+ concentration. Nebracetam hydrochloride exhibits an EC50 of 1.59 mM for elevating [Ca2+]i[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
In Vivo	Nebracetam (10 mg/kg, p.o.) involves not only cholinergic mechanisms but also involves lymbic and hippocampal noradrenergic mechanisms[2]. Animal Model: Male Wistar rats weighing 200-250 g[2]. Dosage: 10, 20 mg/kg. Administration: P.O. (single dose). Result: Able to correct this scopolamine-induced disruption of spatial cognition.
References	[1]. Kitamura Y, et al. Effects of nebracetam (WEB 1881 FU), a novel nootropic, as a M1-muscarinic agonist. Jpn J Pharmacol. 1991 Jan;55(1):177-80. [2]. Iwasaki K, et al. Effect of nebracetam on the disruption of spatial cognition in rats. Jpn J Pharmacol. 1992 Feb;58(2):117-26.

Molecular Formula	C₁₂H₁₇ClN₂O
Molecular Weight	240.73