631864-00-1
631864-00-1 structure
- Name: XL-844
- Chemical Name: XL-844
- CAS Number: 631864-00-1
- Molecular Formula: C14H17N5O2
- Molecular Weight: 287.323
- Create Date: 2020-01-20 13:14:55
- Modify Date: 2023-02-03 12:16:05
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A potent, specific, orally available, ATP‑competitive inhibitor of Chk1 and Chk2 with Ki of 2.2 nM and 0.07 nM, respectively; increases gemcitabine-induced H2AX phosphorylation, blocks Cdc25A phosphorylation, and induces premature mitotic entry; significantly enhances gemcitabine antitumor activity in a PANC-1 xenograft model. Blood Cancer Phase 1 Discontinued
| Name | XL-844 |
|---|
| Description | A potent, specific, orally available, ATP‑competitive inhibitor of Chk1 and Chk2 with Ki of 2.2 nM and 0.07 nM, respectively; increases gemcitabine-induced H2AX phosphorylation, blocks Cdc25A phosphorylation, and induces premature mitotic entry; significantly enhances gemcitabine antitumor activity in a PANC-1 xenograft model. Blood Cancer Phase 1 Discontinued |
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| References | References 1. Riesterer O, et al. Invest New Drugs. 2011 Jun;29(3):514-22. 2. Matthews DJ, et al. Cell Cycle. 2007 Jan 1;6(1):104-10. View Related Products by Target Checkpoint Kinase (Chk) Blood Cancer |
| Molecular Formula | C14H17N5O2 |
|---|---|
| Molecular Weight | 287.323 |