2305045-76-3
2305045-76-3 structure
- Name: XL 188
- Chemical Name: XL 188
- CAS Number: 2305045-76-3
- Molecular Formula: C32H42N6O4
- Molecular Weight: 574.71
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Deubiquitinase
- Create Date: 2023-05-06 07:13:25
- Modify Date: 2025-09-25 10:11:23
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XL 188 is a potent and selective USP7 inhibitor with IC50 values of 90 nM and 193 nM for USP7 full-length and catalytic domain enzyme, respectively. XL 188 can be used in research of cancer[1].
| Name | XL 188 |
|---|
| Description | XL 188 is a potent and selective USP7 inhibitor with IC50 values of 90 nM and 193 nM for USP7 full-length and catalytic domain enzyme, respectively. XL 188 can be used in research of cancer[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Xl 188 (1-20 μm; 16 h; MCF7 细胞) 促进 USP7 依赖性 HDM2 的丢失和 p53 和 p21 的增加[1]。 Western Blot Analysis[1] Cell Line: MCF7 cells Concentration: 1, 5, 10, and 20μM Incubation Time: 16 hours Result: Had the loss of HDM2 accompanied by an increase in downstream tumor suppressors p21 and p53. |
| References |
| Molecular Formula | C32H42N6O4 |
|---|---|
| Molecular Weight | 574.71 |