2095432-47-4
2095432-47-4 structure
- Name: EPZ020411 dihydrochloride
- Chemical Name: EPZ020411 dihydrochloride
- CAS Number: 2095432-47-4
- Molecular Formula: C25H40Cl2N4O3
- Molecular Weight: 515.52
- Create Date: 2020-01-12 11:52:49
- Modify Date: 2024-02-20 07:00:38
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EPZ020411 is a potent, selective PRMT6 inhibitor with IC50 of 10 nM, displays 10-fold and 20-fold selectivity over PRMT1/8, and >100-fold over other histone methyltransferases (PRMT3/4/5/7); dose-dependently decreases H3R2 methylation A375 cell line with IC50 of 0.637 uM, with no affect levels of PRMT6 expression; exhibits good bioavailability following subcutaneous dosing in rats making it a suitable tool for potential in vivo target validation studies.
| Name | EPZ020411 dihydrochloride |
|---|
| Description | EPZ020411 is a potent, selective PRMT6 inhibitor with IC50 of 10 nM, displays 10-fold and 20-fold selectivity over PRMT1/8, and >100-fold over other histone methyltransferases (PRMT3/4/5/7); dose-dependently decreases H3R2 methylation A375 cell line with IC50 of 0.637 uM, with no affect levels of PRMT6 expression; exhibits good bioavailability following subcutaneous dosing in rats making it a suitable tool for potential in vivo target validation studies. |
|---|---|
| References | References 1. Mitchell LH, et al. ACS Med Chem Lett. 2015 Apr 6;6(6):655-9. View Related Products by Target Histone Methyltransferase (HMTase) |
| Molecular Formula | C25H40Cl2N4O3 |
|---|---|
| Molecular Weight | 515.52 |