1934301-68-4
1934301-68-4 structure
- Name: MRK-A
- Chemical Name: MRK-A
- CAS Number: 1934301-68-4
- Molecular Formula: C28H30N4O2
- Molecular Weight: 454.574
- Create Date: 2020-01-15 18:31:29
- Modify Date: 2024-02-24 20:10:28
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MRK-A is a potent, highly selective, brain penetrant inhibitor of mutant IDH1 with IC50 of 5 nM, displays a 10,000-fold mutant to wildtype selectivity ratio; decreases ntracellular 2-HG levels both in vitro and in vivo, inhibits 2-HG production in both BT142 and GB10 intracranial xenografts, as well as tumor growth.
| Name | MRK-A |
|---|
| Description | MRK-A is a potent, highly selective, brain penetrant inhibitor of mutant IDH1 with IC50 of 5 nM, displays a 10,000-fold mutant to wildtype selectivity ratio; decreases ntracellular 2-HG levels both in vitro and in vivo, inhibits 2-HG production in both BT142 and GB10 intracranial xenografts, as well as tumor growth. |
|---|---|
| References | References 1. Kopinja J, et al. Sci Rep. 2017 Oct 23;7(1):13853. View Related Products by Target Isocitrate Dehydrogenase (IDH) |
| Molecular Formula | C28H30N4O2 |
|---|---|
| Molecular Weight | 454.574 |