677772-84-8

677772-84-8 structure

Name: MRK 560
Chemical Name: N-{cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohe xyl}-1,1,1-trifluoromethanesulfonamide
CAS Number: 677772-84-8
Molecular Formula: C₁₉H₁₇ClF₅NO₄S₂
Molecular Weight: 517.92
Catalog: Research Areas Neurological Disease
Create Date: 2016-02-02 13:39:28
Modify Date: 2024-01-05 11:42:29
MRK-560 is a potent, orally bioavailable and brain-penetrant γ-secretase inhibitor[1].

Name	N-{cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohe xyl}-1,1,1-trifluoromethanesulfonamide

Description	MRK-560 is a potent, orally bioavailable and brain-penetrant γ-secretase inhibitor[1].
Related Catalog	Research Areas >> Neurological Disease
Target	γ-secretase[1]
References	[1]. Best JD, et al. The novel gamma secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) reduces amyloid plaque deposition without evidence of notch-related pathology in the Tg2576 mouse. J Pharmacol Exp Ther. 2007 Feb;320(2):552-8.