MRK-A
Modify Date: 2025-09-17 21:43:43
MRK-A structure
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Common Name | MRK-A | ||
|---|---|---|---|---|
| CAS Number | 1934301-68-4 | Molecular Weight | 454.574 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H30N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MRK-AMRK-A is a potent, highly selective, brain penetrant inhibitor of mutant IDH1 with IC50 of 5 nM, displays a 10,000-fold mutant to wildtype selectivity ratio; decreases ntracellular 2-HG levels both in vitro and in vivo, inhibits 2-HG production in both BT142 and GB10 intracranial xenografts, as well as tumor growth. |
| Name | MRK-A |
|---|
| Description | MRK-A is a potent, highly selective, brain penetrant inhibitor of mutant IDH1 with IC50 of 5 nM, displays a 10,000-fold mutant to wildtype selectivity ratio; decreases ntracellular 2-HG levels both in vitro and in vivo, inhibits 2-HG production in both BT142 and GB10 intracranial xenografts, as well as tumor growth. |
|---|---|
| References | References 1. Kopinja J, et al. Sci Rep. 2017 Oct 23;7(1):13853. View Related Products by Target Isocitrate Dehydrogenase (IDH) |
| Molecular Formula | C28H30N4O2 |
|---|---|
| Molecular Weight | 454.574 |