1613168-64-1
1613168-64-1 structure
- Name: MNK-IN-54
- Chemical Name: MNK-IN-54
- CAS Number: 1613168-64-1
- Molecular Formula: C30H32F4N6O2
- Molecular Weight: 584.62
- Create Date: 2020-01-20 13:20:57
- Modify Date: 2024-02-27 12:42:19
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MNK-IN-54 is a potent, orally bioavailable dual MNK1/2 and BCR-ABL1 inhibitor with IC50 of 20/10/200/10 nM for Abl T315I/ wt Abl/MNK1/MNK2, respectively; also inhibits RET, FLT3, VEGFR2 with IC50 <20 nM; shows GI50 of 51 nM in the growth of K562 cells overexpressing eIF4E; exhibits antitumor activity in a mouse xenograft model and also reduces the level of phosphorylated eukaryotic translation initiation factor 4E in the tumor tissues.
| Name | MNK-IN-54 |
|---|
| Description | MNK-IN-54 is a potent, orally bioavailable dual MNK1/2 and BCR-ABL1 inhibitor with IC50 of 20/10/200/10 nM for Abl T315I/ wt Abl/MNK1/MNK2, respectively; also inhibits RET, FLT3, VEGFR2 with IC50 <20 nM; shows GI50 of 51 nM in the growth of K562 cells overexpressing eIF4E; exhibits antitumor activity in a mouse xenograft model and also reduces the level of phosphorylated eukaryotic translation initiation factor 4E in the tumor tissues. |
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| References | References 1. Cherian J, et al. J Med Chem. 2016 Apr 14;59(7):3063-78. View Related Products by Target MNK |
| Molecular Formula | C30H32F4N6O2 |
|---|---|
| Molecular Weight | 584.62 |