1394122-49-6
1394122-49-6 structure
- Name: ADAMTS-5 inhibitor 15f
- Chemical Name: ADAMTS-5 inhibitor 15f
- CAS Number: 1394122-49-6
- Molecular Formula: C26H39N9O2S
- Molecular Weight: 541.719
- Create Date: 2020-01-19 20:28:56
- Modify Date: 2025-08-31 23:06:34
-
ADAMTS-5 inhibitor 15f is a highly potent and selective inhibitor of metalloprotease ADAMTS-5 with IC50 of 30 nM, >50-fold selectivity against ADAMTS-4 and >1000-fold selectivity against ADAMTS-1/13, MMP-13 and TACE; inhibits aggrecanase-mediated (374)ARGS neoepitope release from aggrecan and glycosaminoglycan in response to IL-1β/OSM stimulation.
| Name | ADAMTS-5 inhibitor 15f |
|---|
| Description | ADAMTS-5 inhibitor 15f is a highly potent and selective inhibitor of metalloprotease ADAMTS-5 with IC50 of 30 nM, >50-fold selectivity against ADAMTS-4 and >1000-fold selectivity against ADAMTS-1/13, MMP-13 and TACE; inhibits aggrecanase-mediated (374)ARGS neoepitope release from aggrecan and glycosaminoglycan in response to IL-1β/OSM stimulation. |
|---|---|
| References | References 1. Deng H, et al. J Med Chem. 2012 Aug 23;55(16):7061-79. View Related Products by Target Matrix Metalloproteinase (MMP) |
| Molecular Formula | C26H39N9O2S |
|---|---|
| Molecular Weight | 541.719 |