DC Chemicals Limited
China
Product Name: TCS PrP Inhibitor 13
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3-(4-NITROPHENYL)-1-PHENYL-2-PYRAZOLIN-5-ONE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

34320-83-7

34320-83-7 structure

Name: CAY10550
Chemical Name: 5-(4-nitrophenyl)-2-phenyl-4H-pyrazol-3-one
CAS Number: 34320-83-7
Molecular Formula: C₁₅H₁₁N₃O₃
Molecular Weight: 281.27
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2016-08-13 17:55:36
Modify Date: 2024-01-12 19:14:58
TCS PrP Inhibitor 13, an antiprion agent, is a cellular prion protein (PrPC) inhibitor. TCS PrP Inhibitor 13, as a protease-resistant form of prion protein (PrP-res) accumulation inhibitor, shows an IC50 value of 3 nM in both ScN2a and F3 cell lines. TCS PrP Inhibitor 13 induces Schwannoma cells apoptosis[1].

Name	5-(4-nitrophenyl)-2-phenyl-4H-pyrazol-3-one
Synonyms	TCS PRP INHIBITOR 13 Necrosulfonamide 1-Phenyl-3-p-nitrophenylpyrazolon 3H-Pyrazol-3-one, 2,4-dihydro-5-(4-nitrophenyl)-2-phenyl- 5-(4-Nitrophenyl)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one

Description	TCS PrP Inhibitor 13, an antiprion agent, is a cellular prion protein (PrPC) inhibitor. TCS PrP Inhibitor 13, as a protease-resistant form of prion protein (PrP-res) accumulation inhibitor, shows an IC50 value of 3 nM in both ScN2a and F3 cell lines. TCS PrP Inhibitor 13 induces Schwannoma cells apoptosis[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Infection
Target	IC50: 3 nM (PrPC in ScN2a and F3 cells)[1]
In Vitro	TCS PrP Inhibitor 13 (0~500 μM; Schwannoma cells) significantly reduces levels of total ERK1/2, pAKT, total FAK, Cyclin D1, PrPC and significantly increases expression of cleaved caspase-3. TCS PrP Inhibitor 13 (Schwannoma cells) significantly reduces the number of proliferating, Ki67-positive cells and total cell number[2].
References	[1]. Kimata A, et al. New series of antiprion compounds: pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulation [published correction appears in J Med Chem. 2008 Mar 13;51(5):1503]. J Med Chem. 2007;50(21):5053-5056. [2]. Provenzano L, et al. Cellular prion protein (PrPC) in the development of Merlin-deficient tumours. Oncogene. 2017;36(44):6132-6142.

Density	1.4±0.1 g/cm3
Boiling Point	445.1±47.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₁N₃O₃
Molecular Weight	281.27
Flash Point	223.0±29.3 °C
Exact Mass	281.080048
PSA	78.49000
LogP	1.92
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.674

HS Code	2933199090

838-57-3

100-63-0

~82%

34320-83-7

Literature: Kimata, Ayako; Nakagawa, Hidehiko; Ohyama, Ryo; Fukuuchi, Tomoko; Ohta, Shigeru; Suzuki, Takayoshi; Miyata, Naoki Journal of Medicinal Chemistry, 2007 , vol. 50, # 21 p. 5053 - 5056

89-25-8

61466-08-8

~0%

61466-03-3

34320-83-7

Literature: Azev; Teplyashina Chemistry of Heterocyclic Compounds, 1998 , vol. 34, # 9 p. 1091 - 1092

Precursor 4
838-57-3 100-63-0 89-25-8 61466-08-8
DownStream 0

HS Code	2933199090
Summary	2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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