26927-01-5
26927-01-5 structure
- Name: 7DG
- Chemical Name: 7DG
- CAS Number: 26927-01-5
- Molecular Formula: C26H30O5
- Molecular Weight: 422.51
- Catalog: Signaling Pathways Cell Cycle/DNA Damage PERK
- Create Date: 2020-01-11 21:30:50
- Modify Date: 2025-08-27 16:07:28
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7DG (7-Desacetoxy-6,7-dehydrogedunin) is a selective inhibitor of protein kinase R (PKR) that directly interact with the C-terminal of PKR; completely protectes macrophages from anthrax lethal toxin (LT)-induced pyroptotic cell death, a model for inflammasome-mediated caspase-1 activation, with an (IC50) of 5 uM.
| Name | 7DG |
|---|
| Description | 7DG (7-Desacetoxy-6,7-dehydrogedunin) is a selective inhibitor of protein kinase R (PKR) that directly interact with the C-terminal of PKR; completely protectes macrophages from anthrax lethal toxin (LT)-induced pyroptotic cell death, a model for inflammasome-mediated caspase-1 activation, with an (IC50) of 5 uM. |
|---|---|
| References | References 1. Hett EC, et al. Nat Chem Biol. 2013 Jun;9(6):398-405. View Related Products by Target Other Targets |
| Molecular Formula | C26H30O5 |
|---|---|
| Molecular Weight | 422.51 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Hazard Codes | Xn |
| RIDADR | NONH for all modes of transport |