1838123-21-9
1838123-21-9 structure
- Name: CXCR2-IN-68
- Chemical Name: CXCR2-IN-68
- CAS Number: 1838123-21-9
- Molecular Formula: C18H23ClN2O5S
- Molecular Weight: 414.901
- Create Date: 2020-01-11 18:43:50
- Modify Date: 2024-09-20 14:07:17
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CXCR2-IN-68 is a potent, selective, brain penetrant, and orally bioavailable CXCR2 antagonist with pIC50 of 9.0, displays 730-fold selectivity over CXCR1 and >1,900-fold selectivity over all other chemokine receptors; inhibits human whole blood Gro-α induced CD11b expression with IC50 of 0.04 µM, 17-fold more potent than Navarixin; significantly inhibits neutrophil infiltration in mouse at 1, 3, 10 mg/kg oral dosing twice daily (BID).
| Name | CXCR2-IN-68 |
|---|
| Description | CXCR2-IN-68 is a potent, selective, brain penetrant, and orally bioavailable CXCR2 antagonist with pIC50 of 9.0, displays 730-fold selectivity over CXCR1 and >1,900-fold selectivity over all other chemokine receptors; inhibits human whole blood Gro-α induced CD11b expression with IC50 of 0.04 µM, 17-fold more potent than Navarixin; significantly inhibits neutrophil infiltration in mouse at 1, 3, 10 mg/kg oral dosing twice daily (BID). |
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| References | References 1. Lu H, et al. J Med Chem. 2018 Feb 28. doi: 10.1021/acs.jmedchem.7b01854. View Related Products by Target Chemokine Receptor (CCR and CXCR) |
| Molecular Formula | C18H23ClN2O5S |
|---|---|
| Molecular Weight | 414.901 |