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2416925-03-4

2416925-03-4 structure

2416925-03-4 structure

Name: EGFR-IN-68
Chemical Name: EGFR-IN-68
CAS Number: 2416925-03-4
Molecular Formula: C₂₄H₂₂N₂O
Molecular Weight: 354.44
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2022-09-12 12:12:12
Modify Date: 2024-01-11 11:50:58
EGFR-IN-68 (Compound 8d) is a potent EGFR inhibitor with an IC50 of 0.33 μM. EGFR-IN-68 shows anticancer activity[1].

Name	EGFR-IN-68

Description	EGFR-IN-68 (Compound 8d) is a potent EGFR inhibitor with an IC50 of 0.33 μM. EGFR-IN-68 shows anticancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
In Vitro	EGFR-IN-68 (Compound 8d) shows cytotoxicity with IC50 values of 3.79 ± 0.04 μM and 25.56 ± 1.59 μM against MCF-7 and WI-38, respectively[1].
References	[1]. George RF, et al. Some 1,3,5-trisubstituted pyrazoline derivatives targeting breast cancer: Design, synthesis, cytotoxic activity, EGFR inhibition and molecular docking. Bioorg Chem. 2020 Jun;99:103780.

Molecular Formula	C₂₄H₂₂N₂O
Molecular Weight	354.44

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