1807453-72-0
1807453-72-0 structure
- Name: ND-378
- Chemical Name: ND-378
- CAS Number: 1807453-72-0
- Molecular Formula: C18H19NO4S2
- Molecular Weight: 377.473
- Create Date: 2020-01-12 07:44:50
- Modify Date: 2024-01-02 22:03:09
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A potent, selective MMP-2 inhibitor with Ki of 230 nM; does not inhibit the closely related MMP-9 or MMP-14, and other MMPs (Ki>50 uM); can cross the blood-spinal cord barrier, achieving therapeutic concentrations in the injured spinal cord, shows no change in long-term neurological outcomes in mice.
| Name | ND-378 |
|---|
| Description | A potent, selective MMP-2 inhibitor with Ki of 230 nM; does not inhibit the closely related MMP-9 or MMP-14, and other MMPs (Ki>50 uM); can cross the blood-spinal cord barrier, achieving therapeutic concentrations in the injured spinal cord, shows no change in long-term neurological outcomes in mice. |
|---|---|
| References | References 1. Gao M, et al. ACS Chem Neurosci. 2016 Nov 16;7(11):1482-1487. View Related Products by Target Matrix Metalloproteinase (MMP) |
| Molecular Formula | C18H19NO4S2 |
|---|---|
| Molecular Weight | 377.473 |