ND-378
Modify Date: 2025-08-25 19:36:41
ND-378 structure
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Common Name | ND-378 | ||
|---|---|---|---|---|
| CAS Number | 1807453-72-0 | Molecular Weight | 377.473 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H19NO4S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ND-378A potent, selective MMP-2 inhibitor with Ki of 230 nM; does not inhibit the closely related MMP-9 or MMP-14, and other MMPs (Ki>50 uM); can cross the blood-spinal cord barrier, achieving therapeutic concentrations in the injured spinal cord, shows no change in long-term neurological outcomes in mice. |
| Name | ND-378 |
|---|
| Description | A potent, selective MMP-2 inhibitor with Ki of 230 nM; does not inhibit the closely related MMP-9 or MMP-14, and other MMPs (Ki>50 uM); can cross the blood-spinal cord barrier, achieving therapeutic concentrations in the injured spinal cord, shows no change in long-term neurological outcomes in mice. |
|---|---|
| References | References 1. Gao M, et al. ACS Chem Neurosci. 2016 Nov 16;7(11):1482-1487. View Related Products by Target Matrix Metalloproteinase (MMP) |
| Molecular Formula | C18H19NO4S2 |
|---|---|
| Molecular Weight | 377.473 |
| InChIKey | AQVLOPBRNWYJSU-UHFFFAOYSA-N |
| SMILES | CC(=O)NCc1ccc(Oc2ccc(S(=O)(=O)CC3CS3)cc2)cc1 |