1137233-79-4
1137233-79-4 structure
- Name: RO 5126946
- Chemical Name: RO 5126946
- CAS Number: 1137233-79-4
- Molecular Formula: C19H21ClN2O4S
- Molecular Weight: 408.897
- Create Date: 2020-01-20 12:10:56
- Modify Date: 2023-04-05 12:16:20
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A novel potent, selective, orally bioavailable and brain-penetran α7nAChR positive allosteric modulator with EC50 of 60 nM; shows excellent selectivity over α4β2nAChR and 5-hydroxytryptamine 3 receptors; enhances α7nAChR synaptic transmission and positively modulates GABAergic responses; improves associative learning in a scopolamine-induced deficit model of fear conditioning in rats, potentiates nicotine's effects on fear memory in vivo.
| Name | RO 5126946 |
|---|
| Description | A novel potent, selective, orally bioavailable and brain-penetran α7nAChR positive allosteric modulator with EC50 of 60 nM; shows excellent selectivity over α4β2nAChR and 5-hydroxytryptamine 3 receptors; enhances α7nAChR synaptic transmission and positively modulates GABAergic responses; improves associative learning in a scopolamine-induced deficit model of fear conditioning in rats, potentiates nicotine's effects on fear memory in vivo. |
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| References | References 1. Sahdeo S, et al. J Pharmacol Exp Ther. 2014 Aug;350(2):455-68. View Related Products by Target nAChR |
| Molecular Formula | C19H21ClN2O4S |
|---|---|
| Molecular Weight | 408.897 |