RO 5126946

Modify Date: 2025-08-26 17:19:18

RO 5126946 Structure
RO 5126946 structure
 Common Name RO 5126946
CAS Number 1137233-79-4 Molecular Weight 408.897
Density N/A Boiling Point N/A
Molecular Formula C19H21ClN2O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of RO 5126946


A novel potent, selective, orally bioavailable and brain-penetran α7nAChR positive allosteric modulator with EC50 of 60 nM; shows excellent selectivity over α4β2nAChR and 5-hydroxytryptamine 3 receptors; enhances α7nAChR synaptic transmission and positively modulates GABAergic responses; improves associative learning in a scopolamine-induced deficit model of fear conditioning in rats, potentiates nicotine's effects on fear memory in vivo.

 Names

Name RO 5126946

 RO 5126946 Biological Activity

Description A novel potent, selective, orally bioavailable and brain-penetran α7nAChR positive allosteric modulator with EC50 of 60 nM; shows excellent selectivity over α4β2nAChR and 5-hydroxytryptamine 3 receptors; enhances α7nAChR synaptic transmission and positively modulates GABAergic responses; improves associative learning in a scopolamine-induced deficit model of fear conditioning in rats, potentiates nicotine's effects on fear memory in vivo.
References References 1. Sahdeo S, et al. J Pharmacol Exp Ther. 2014 Aug;350(2):455-68. View Related Products by Target nAChR

 Chemical & Physical Properties

Molecular Formula C19H21ClN2O4S
Molecular Weight 408.897
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Chemsrc provides RO 5126946(CAS#:1137233-79-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of RO 5126946 are included as well.>> amp version: RO 5126946

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