RO 5126946
Modify Date: 2023-04-05 12:16:20
RO 5126946 structure
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Common Name | RO 5126946 | ||
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| CAS Number | 1137233-79-4 | Molecular Weight | 408.897 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H21ClN2O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of RO 5126946A novel potent, selective, orally bioavailable and brain-penetran α7nAChR positive allosteric modulator with EC50 of 60 nM; shows excellent selectivity over α4β2nAChR and 5-hydroxytryptamine 3 receptors; enhances α7nAChR synaptic transmission and positively modulates GABAergic responses; improves associative learning in a scopolamine-induced deficit model of fear conditioning in rats, potentiates nicotine's effects on fear memory in vivo. |
| Name | RO 5126946 |
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| Description | A novel potent, selective, orally bioavailable and brain-penetran α7nAChR positive allosteric modulator with EC50 of 60 nM; shows excellent selectivity over α4β2nAChR and 5-hydroxytryptamine 3 receptors; enhances α7nAChR synaptic transmission and positively modulates GABAergic responses; improves associative learning in a scopolamine-induced deficit model of fear conditioning in rats, potentiates nicotine's effects on fear memory in vivo. |
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| References | References 1. Sahdeo S, et al. J Pharmacol Exp Ther. 2014 Aug;350(2):455-68. View Related Products by Target nAChR |
| Molecular Formula | C19H21ClN2O4S |
|---|---|
| Molecular Weight | 408.897 |