433234-16-3
433234-16-3 structure
- Name: TRAF-STOP 6860766
- Chemical Name: (2E)-3-[(4-Bromo-2-chlorophenyl)amino]-1-phenyl-2-propen-1-one
- CAS Number: 433234-16-3
- Molecular Formula: C15H11BrClNO
- Molecular Weight: 336.611
- Create Date: 2020-01-11 19:36:00
- Modify Date: 2024-01-07 12:02:21
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TRAF-STOP 6860766 (SMI-6860766, SMI6860766) is a small molecule inhibitor that blocks the interaction between CD40 and TRAF6 (TRAF-STOP), while leaving CD40-TRAF2/3/5 interactions intact, thereby preserving CD40-mediated immunity; prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation; reduces the CD40-induced phosphorylation of Tak1 and NF-κB p65 in BMDMs.
| Name | (2E)-3-[(4-Bromo-2-chlorophenyl)amino]-1-phenyl-2-propen-1-one |
|---|---|
| Synonyms |
(2E)-3-[(4-Bromo-2-chlorophenyl)amino]-1-phenyl-2-propen-1-one
MFCD02911428 2-Propen-1-one, 3-[(4-bromo-2-chlorophenyl)amino]-1-phenyl-, (2E)- |
| Description | TRAF-STOP 6860766 (SMI-6860766, SMI6860766) is a small molecule inhibitor that blocks the interaction between CD40 and TRAF6 (TRAF-STOP), while leaving CD40-TRAF2/3/5 interactions intact, thereby preserving CD40-mediated immunity; prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation; reduces the CD40-induced phosphorylation of Tak1 and NF-κB p65 in BMDMs. |
|---|---|
| References | References 1. Seijkens TTP, et al. J Am Coll Cardiol. 2018 Feb 6;71(5):527-542. View Related Products by Target Other Targets |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 417.5±45.0 °C at 760 mmHg |
| Molecular Formula | C15H11BrClNO |
| Molecular Weight | 336.611 |
| Flash Point | 206.3±28.7 °C |
| Exact Mass | 334.971252 |
| LogP | 4.54 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.664 |