TRAF-STOP 6860766
Modify Date: 2025-08-22 19:12:24
TRAF-STOP 6860766 structure
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Common Name | TRAF-STOP 6860766 | ||
|---|---|---|---|---|
| CAS Number | 433234-16-3 | Molecular Weight | 336.611 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 417.5±45.0 °C at 760 mmHg | |
| Molecular Formula | C15H11BrClNO | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 206.3±28.7 °C | |
Use of TRAF-STOP 6860766TRAF-STOP 6860766 (SMI-6860766, SMI6860766) is a small molecule inhibitor that blocks the interaction between CD40 and TRAF6 (TRAF-STOP), while leaving CD40-TRAF2/3/5 interactions intact, thereby preserving CD40-mediated immunity; prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation; reduces the CD40-induced phosphorylation of Tak1 and NF-κB p65 in BMDMs. |
| Name | (2E)-3-[(4-Bromo-2-chlorophenyl)amino]-1-phenyl-2-propen-1-one |
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| Synonym | More Synonyms |
| Description | TRAF-STOP 6860766 (SMI-6860766, SMI6860766) is a small molecule inhibitor that blocks the interaction between CD40 and TRAF6 (TRAF-STOP), while leaving CD40-TRAF2/3/5 interactions intact, thereby preserving CD40-mediated immunity; prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation; reduces the CD40-induced phosphorylation of Tak1 and NF-κB p65 in BMDMs. |
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| References | References 1. Seijkens TTP, et al. J Am Coll Cardiol. 2018 Feb 6;71(5):527-542. View Related Products by Target Other Targets |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 417.5±45.0 °C at 760 mmHg |
| Molecular Formula | C15H11BrClNO |
| Molecular Weight | 336.611 |
| Flash Point | 206.3±28.7 °C |
| Exact Mass | 334.971252 |
| LogP | 4.54 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.664 |
| InChIKey | HYNIWWUIOZKCKS-CMDGGOBGSA-N |
| SMILES | O=C(C=CNc1ccc(Br)cc1Cl)c1ccccc1 |
| (2E)-3-[(4-Bromo-2-chlorophenyl)amino]-1-phenyl-2-propen-1-one |
| MFCD02911428 |
| 2-Propen-1-one, 3-[(4-bromo-2-chlorophenyl)amino]-1-phenyl-, (2E)- |