433249-94-6

433249-94-6 structure

Name: TRAF-STOP inhibitor 6877002
Chemical Name: (2E)-3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one
CAS Number: 433249-94-6
Molecular Formula: C₁₇H₁₇NO
Molecular Weight: 251.323
Catalog: Signaling Pathways Apoptosis TNF Receptor
Create Date: 2018-07-07 21:59:22
Modify Date: 2024-01-11 12:59:51
TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction, compound VII, shows inhibition of NF-κB activation in RAW cells, extracted from patent WO2014033122A1[1]. TRAF-STOP 6877002 prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation; reduces macrophage proliferation in atherosclerotic plaques[2].

Name	(2E)-3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one
Synonyms	(2E)-3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one 2-Propen-1-one, 3-[(2,5-dimethylphenyl)amino]-1-phenyl-, (2E)-

Description	TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction, compound VII, shows inhibition of NF-κB activation in RAW cells, extracted from patent WO2014033122A1[1]. TRAF-STOP 6877002 prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation; reduces macrophage proliferation in atherosclerotic plaques[2].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology Signaling Pathways >> Apoptosis >> TNF Receptor
Target	CD40-TRAF6 interaction; NF-κB
References	[1]. Seijkens TTP, et al. Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis. J Am Coll Cardiol. 2018 Feb 6;71(5):527-542.