TRAF-STOP inhibitor 6877002
Modify Date: 2025-08-25 08:31:13
TRAF-STOP inhibitor 6877002 structure
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Common Name | TRAF-STOP inhibitor 6877002 | ||
|---|---|---|---|---|
| CAS Number | 433249-94-6 | Molecular Weight | 251.323 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 378.6±42.0 °C at 760 mmHg | |
| Molecular Formula | C17H17NO | Melting Point | N/A | |
| MSDS | USA | Flash Point | 133.5±28.0 °C | |
| Symbol |
GHS09 |
Signal Word | ||
Use of TRAF-STOP inhibitor 6877002TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction, compound VII, shows inhibition of NF-κB activation in RAW cells, extracted from patent WO2014033122A1[1]. TRAF-STOP 6877002 prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation; reduces macrophage proliferation in atherosclerotic plaques[2]. |
| Name | (2E)-3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one |
|---|---|
| Synonym | More Synonyms |
| Description | TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction, compound VII, shows inhibition of NF-κB activation in RAW cells, extracted from patent WO2014033122A1[1]. TRAF-STOP 6877002 prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation; reduces macrophage proliferation in atherosclerotic plaques[2]. |
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| Related Catalog | |
| Target |
CD40-TRAF6 interaction; NF-κB |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 378.6±42.0 °C at 760 mmHg |
| Molecular Formula | C17H17NO |
| Molecular Weight | 251.323 |
| Flash Point | 133.5±28.0 °C |
| Exact Mass | 251.131012 |
| LogP | 3.83 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.619 |
| InChIKey | SARYOFMRLSHZFE-ZHACJKMWSA-N |
| SMILES | Cc1ccc(C)c(NC=CC(=O)c2ccccc2)c1 |
| Symbol |
GHS09 |
|---|---|
| Hazard Statements | H411 |
| Precautionary Statements | P273-P391-P501 |
| Hazard Codes | N |
| RIDADR | UN 3077 9 / PGIII |
| (2E)-3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one |
| 2-Propen-1-one, 3-[(2,5-dimethylphenyl)amino]-1-phenyl-, (2E)- |