912798-81-3
912798-81-3 structure
- Name: LDN-75654
- Chemical Name: N-(3-Chloro-4-fluorophenyl)-5-isopropyl-1,2-oxazole-3-carboxamide
- CAS Number: 912798-81-3
- Molecular Formula: C13H12ClFN2O2
- Molecular Weight: 282.698
- Create Date: 2020-01-11 17:32:26
- Modify Date: 2024-01-06 19:36:53
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LDN-75654 is a novel potent SMN2 modulator (EC50=1.8 uM; Emax 186%), increases SMN protein in spinal cord and brain in mice.
| Name | N-(3-Chloro-4-fluorophenyl)-5-isopropyl-1,2-oxazole-3-carboxamide |
|---|---|
| Synonyms |
3-Isoxazolecarboxamide, N-(3-chloro-4-fluorophenyl)-5-(1-methylethyl)-
N-(3-Chloro-4-fluorophenyl)-5-isopropyl-1,2-oxazole-3-carboxamide |
| Description | LDN-75654 is a novel potent SMN2 modulator (EC50=1.8 uM; Emax 186%), increases SMN protein in spinal cord and brain in mice. |
|---|---|
| References | References 1. Rietz A, et al. J Med Chem. 2017 Jun 8;60(11):4594-4610. View Related Products by Target SMN2 Modulator |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 327.9±42.0 °C at 760 mmHg |
| Molecular Formula | C13H12ClFN2O2 |
| Molecular Weight | 282.698 |
| Flash Point | 152.1±27.9 °C |
| Exact Mass | 282.057129 |
| LogP | 3.51 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.582 |