1627503-67-6
1627503-67-6 structure
- Name: LDN 214117
- Chemical Name: 1-{4-[6-Methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl}piperazine
- CAS Number: 1627503-67-6
- Molecular Formula: C25H29N3O3
- Molecular Weight: 419.516
- Catalog: Biochemical Inhibitor TGF-beta/Smad signaling pathway inhibitor (TGF-beta/Smad) TGF-beta/Smad inhibitor
- Create Date: 2018-03-22 12:04:28
- Modify Date: 2024-01-10 13:07:45
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LDN-214117 is a potent and selective ALK2 inhibitor with IC50 of 22 nM; > 100 fold selectivity for ALK5; also inhibits BMP6(IC50=100 nM).IC50 value: 22 nM(ALK2) [1]Target: ALK2 inhibitorLDN-214117 is a highly BMP selective compound, significantly biased toward ALK2 and its cognate ligands including BMP6 and also demonstrates a high degree of kinome selectivity and lowcytotoxicity. LDN-214117 may be useful as highly selectiveprobes of BMP-mediated cellular physiology that may provide auseful complement to the dorsomorphin class of compounds. Furthermore, this class of BMP inhibitors offers a structurallydistinct template for the development of therapeutics for thetreatment of BMP signaling-mediated diseases such as FOP.
| Name | 1-{4-[6-Methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl}piperazine |
|---|---|
| Synonyms |
1-{4-[6-Methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl}piperazine
Piperazine, 1-[4-[6-methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl]- LDN-214117 |
| Description | LDN-214117 is a potent and selective ALK2 inhibitor with IC50 of 22 nM; > 100 fold selectivity for ALK5; also inhibits BMP6(IC50=100 nM).IC50 value: 22 nM(ALK2) [1]Target: ALK2 inhibitorLDN-214117 is a highly BMP selective compound, significantly biased toward ALK2 and its cognate ligands including BMP6 and also demonstrates a high degree of kinome selectivity and lowcytotoxicity. LDN-214117 may be useful as highly selectiveprobes of BMP-mediated cellular physiology that may provide auseful complement to the dorsomorphin class of compounds. Furthermore, this class of BMP inhibitors offers a structurallydistinct template for the development of therapeutics for thetreatment of BMP signaling-mediated diseases such as FOP. |
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| Related Catalog | |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 567.9±50.0 °C at 760 mmHg |
| Molecular Formula | C25H29N3O3 |
| Molecular Weight | 419.516 |
| Flash Point | 297.3±30.1 °C |
| Exact Mass | 419.220886 |
| LogP | 3.27 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.573 |
| Storage condition | 2-8°C |