886041-60-7
886041-60-7 structure
- Name: MK-3281
- Chemical Name: MK-3281
- CAS Number: 886041-60-7
- Molecular Formula: C29H37N3O3
- Molecular Weight: 475.622
- Create Date: 2020-01-20 12:06:56
- Modify Date: 2023-01-17 11:46:20
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MK-3281 is a potent and orally bioavailable inhibitor of HCV NS5B polymerase with IC50 of 6 nM; MK-3281 is an equally potent inhibitor of gt 1a (EC50=28 nM), 1b BK (EC50=9 nM), and 3a (EC50=37 nM) replicons, shows 2 orders of magnitude less active on 2a (EC50=2018 nM) and 2b (EC50=1833 nM) replicons; demonstrates consistent decrease in viremia in vivo using the chimeric mouse model of HCV infection. HCV Infection Phase 1 Discontinued
| Name | MK-3281 |
|---|---|
| Synonyms |
(7R)-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl)amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid
6H-Indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid, 14-cyclohexyl-7-[[2-(dimethylamino)ethyl]methylamino]-7,8-dihydro-, (7R)- MK-3281 |
| Description | MK-3281 is a potent and orally bioavailable inhibitor of HCV NS5B polymerase with IC50 of 6 nM; MK-3281 is an equally potent inhibitor of gt 1a (EC50=28 nM), 1b BK (EC50=9 nM), and 3a (EC50=37 nM) replicons, shows 2 orders of magnitude less active on 2a (EC50=2018 nM) and 2b (EC50=1833 nM) replicons; demonstrates consistent decrease in viremia in vivo using the chimeric mouse model of HCV infection. HCV Infection Phase 1 Discontinued |
|---|---|
| References | References 1. Narjes F, et al. J Med Chem. 2011 Jan 13;54(1):289-301. View Related Products by Target HCV HCV Infection |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 681.3±55.0 °C at 760 mmHg |
| Molecular Formula | C29H37N3O3 |
| Molecular Weight | 475.622 |
| Flash Point | 365.8±31.5 °C |
| Exact Mass | 475.283478 |
| LogP | 6.59 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.631 |