796885-38-6
796885-38-6 structure
- Name: MK-4541
- Chemical Name: MK-4541
- CAS Number: 796885-38-6
- Molecular Formula: C22H31F3N2O3
- Molecular Weight: 428.49
- Catalog: Signaling Pathways Metabolic Enzyme/Protease 5 alpha Reductase
- Create Date: 2023-02-18 22:47:37
- Modify Date: 2024-02-04 19:40:42
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MK-4541 is an orally active and selective androgen receptor (AR) modulator. MK-4541 acts as an antagonist to inhibit 5α-reductase. MK-4541 inhibits proliferation and induces apoptosis in AR positive prostate cancer cells. MK-4541 significantly inhibited the growth of R3327-G prostate tumors in xenograft mouse model[1].
| Name | MK-4541 |
|---|---|
| Synonyms | Carbamic acid, N-[(4aR,4bS,6aS,7S,9aS,9bS,11aR)-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1,4a,6a-trimethyl-2-oxo-1H-indeno[5,4-f]quinolin-7-yl]-, 2,2,2-trifluoroethyl ester |
| Description | MK-4541 is an orally active and selective androgen receptor (AR) modulator. MK-4541 acts as an antagonist to inhibit 5α-reductase. MK-4541 inhibits proliferation and induces apoptosis in AR positive prostate cancer cells. MK-4541 significantly inhibited the growth of R3327-G prostate tumors in xenograft mouse model[1]. |
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| Related Catalog | |
| In Vivo | MK-4541 (100 mg/kg; 每天1次，每周5次，持续5周) 抑制含 R-3327-G 细胞的无胸腺裸鼠前列腺肿瘤生长[1]。 MK-4541 (100 mg/kg, 200 mg/kg; 每周5次，持续5周) 对精囊具有抗雄激素作用，降低完好男性的血浆睾酮浓度，并抑制 Ki67 表达[1]。 MK-4541 (15 mg/kg, 50 mg/kg; 每周5次，持续8周) 导致成年阉割小鼠肌肉骨骼质量和功能的损失[1]。 Animal Model: R3327-G prostate tumors in xenograft mouse model[1] Dosage: 25 mg/kg, 50 mg/kg, 100 mg/kg, 200 mg/kg Administration: Oral gavage; once daily, 5 times per week for 5 weeks Result: Significantly inhibited tumor growth at 100 mg/kg, as well as reducing plasma testosterone concentration and Ki67 expression. |
| References |
| Molecular Formula | C22H31F3N2O3 |
|---|---|
| Molecular Weight | 428.49 |