442535-46-8

442535-46-8 structure

Name: CCT-031374
Chemical Name: 2-(1,2-dihydroimidazo[1,2-a]benzimidazol-4-yl)-1-(4-phenylphenyl)ethanone
CAS Number: 442535-46-8
Molecular Formula: C₂₃H₁₉N₃O
Molecular Weight: 353.417
Create Date: 2020-01-11 14:00:26
Modify Date: 2024-01-13 17:53:48
CCT-031374 is a selective β-catenin signaling inhibitor with IC50 of 6.1 uM; prevents BIO-induced accumulation of β-catenin, does not alter β-catenin levels but blocks transcription at the β-catenin level; also shows activity against endogenous LEF-1 mRNA levels in human neurogenic embryoid bodies (hNEBs) in which Wnt signaling had been induced by BIO.

Name	2-(1,2-dihydroimidazo[1,2-a]benzimidazol-4-yl)-1-(4-phenylphenyl)ethanone
Synonyms	2-(1,2-dihydroimidazo[1,2-a]benzimidazol-4-yl)-1-(4-phenylphenyl)ethanone Ethanone, 1-[1,1'-biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)- 1-(4-Biphenylyl)-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)ethanone MFCD01055171 1-Biphenyl-4-yl-2-(2,3-dihydro-1,3a,8-triaza-cyclopenta[a]inden-8-yl)-ethanone 1-(biphenyl-4-yl)-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)ethanone

Description	CCT-031374 is a selective β-catenin signaling inhibitor with IC50 of 6.1 uM; prevents BIO-induced accumulation of β-catenin, does not alter β-catenin levels but blocks transcription at the β-catenin level; also shows activity against endogenous LEF-1 mRNA levels in human neurogenic embryoid bodies (hNEBs) in which Wnt signaling had been induced by BIO.
References	References 1. Ewan K, et al. Cancer Res. 2010 Jul 15;70(14):5963-73. 2. Yang Y, et al. Neuroscience. 2013 Sep 17;248:383-91. 3. Liu B, et al. Int J Mol Med. 2015 Dec;36(6):1572-82. View Related Products by Target Beta-catenin