660822-23-1
660822-23-1 structure
- Name: CCT 068127
- Chemical Name: CCT 068127
- CAS Number: 660822-23-1
- Molecular Formula: C19H27N7O
- Molecular Weight: 369.473
- Create Date: 2020-01-20 10:30:55
- Modify Date: 2024-01-17 11:55:07
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CCT 068127 (CCT68127) is a novel potent inhibitor of CDK2 and CDK9 with IC50 of 10 and 90 nM for CDK2/E and CDK9/T, respectively; also inhibits CDK5/p35, CDK2/A, CDK7/H with IC50 of <1 uM, but without significant activity against ABL, AKT, CAMKII, CK2, ERK2, GSK3 etc.; causes a dramatic loss in expression of DUSP6 phosphatase, alongside elevated ERK phosphorylation and activation of MAPK pathway target genes in cancer cells.
| Name | CCT 068127 |
|---|
| Description | CCT 068127 (CCT68127) is a novel potent inhibitor of CDK2 and CDK9 with IC50 of 10 and 90 nM for CDK2/E and CDK9/T, respectively; also inhibits CDK5/p35, CDK2/A, CDK7/H with IC50 of <1 uM, but without significant activity against ABL, AKT, CAMKII, CK2, ERK2, GSK3 etc.; causes a dramatic loss in expression of DUSP6 phosphatase, alongside elevated ERK phosphorylation and activation of MAPK pathway target genes in cancer cells. |
|---|---|
| References | References 1. Whittaker SR, et al. Mol Oncol. 2017 Oct 24. doi: 10.1002/1878-0261.12148. View Related Products by Target Cyclin-dependent Kinase (CDK) |
| Molecular Formula | C19H27N7O |
|---|---|
| Molecular Weight | 369.473 |