1578244-34-4
1578244-34-4 structure
- Name: CCT-271850
- Chemical Name: N8-[(2S)-3,3-Dimethyl-2-butanyl]-N2-[2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl]pyrido[3,4-d]pyrimidine-2,8-diamine
- CAS Number: 1578244-34-4
- Molecular Formula: C24H29N7O
- Molecular Weight: 431.53
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Mps1
- Create Date: 2019-06-16 13:09:34
- Modify Date: 2023-10-17 15:34:19
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Mps1-IN-7 is a potent MPS1 inhibitor (IC50 of 0.020 μM) over JNK1 and JNK2 (JNK1 IC50 = 0.11 μM, JNK2 IC50=0.22 μM). Mps1-IN-7 inhibit SW620, CAL51, Miapaca-2, RMG1 cell growth with GI50 values of 0.065, 0.068, 0.25, and 0.110 μM,respectively[1].
| Name | N8-[(2S)-3,3-Dimethyl-2-butanyl]-N2-[2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl]pyrido[3,4-d]pyrimidine-2,8-diamine |
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| Synonyms |
N8-[(2S)-3,3-Dimethyl-2-butanyl]-N2-[2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl]pyrido[3,4-d]pyrimidine-2,8-diamine
compound 34h [PMID: 27055065] Pyrido[3,4-d]pyrimidine-2,8-diamine, N2-[2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl]-N8-[(1S)-1,2,2-trimethylpropyl]- MFCD28963915 |
| Description | Mps1-IN-7 is a potent MPS1 inhibitor (IC50 of 0.020 μM) over JNK1 and JNK2 (JNK1 IC50 = 0.11 μM, JNK2 IC50=0.22 μM). Mps1-IN-7 inhibit SW620, CAL51, Miapaca-2, RMG1 cell growth with GI50 values of 0.065, 0.068, 0.25, and 0.110 μM,respectively[1]. |
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| Related Catalog | |
| Target |
IC50: 0.020 μM (MSP1)[1] |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 641.2±65.0 °C at 760 mmHg |
| Molecular Formula | C24H29N7O |
| Molecular Weight | 431.53 |
| Flash Point | 341.6±34.3 °C |
| Exact Mass | 431.243347 |
| LogP | 3.63 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.639 |