1582736-28-4

1582736-28-4 structure

Name: GPR39 modulator 3
Chemical Name: 4-Fluoro-N-({trans-4-[({4-[(2-methoxyethyl)amino]-6-(2-pyridinyl)-2-pyrimidinyl}amino)methyl]cyclohexyl}methyl)benzenesulfonamide
CAS Number: 1582736-28-4
Molecular Formula: C₂₆H₃₃FN₆O₃S
Molecular Weight: 528.642
Create Date: 2020-01-12 13:45:49
Modify Date: 2024-01-19 23:30:25
GPR39 modulator 3 is a Hedgehog pathway inhibitor that has high cellular potency (EC50=5 nM) in the reporter gene assay, activates the orphan receptor GPR39 and potently reduces of Gli1 and Ptch1 mRNA levels; activates the orphan receptor GPR39, which signals to the Gli transcription factors and blocks signaling; a useful chemical tool for in vitro interrogation of GPR39 signaling in different cellular contexts.

Name	4-Fluoro-N-({trans-4-[({4-[(2-methoxyethyl)amino]-6-(2-pyridinyl)-2-pyrimidinyl}amino)methyl]cyclohexyl}methyl)benzenesulfonamide
Synonyms	4-Fluoro-N-(((1r,4r)-4-(((4-((2-methoxyethyl)amino)-6-(pyridin-2-yl)pyrimidin-2-yl)amino)methyl)cyclohexyl)methyl)benzenesulfonamide 4-Fluoro-N-({trans-4-[({4-[(2-methoxyethyl)amino]-6-(2-pyridinyl)-2-pyrimidinyl}amino)methyl]cyclohexyl}methyl)benzenesulfonamide Benzenesulfonamide, 4-fluoro-N-[[trans-4-[[[4-[(2-methoxyethyl)amino]-6-(2-pyridinyl)-2-pyrimidinyl]amino]methyl]cyclohexyl]methyl]-

Description	GPR39 modulator 3 is a Hedgehog pathway inhibitor that has high cellular potency (EC50=5 nM) in the reporter gene assay, activates the orphan receptor GPR39 and potently reduces of Gli1 and Ptch1 mRNA levels; activates the orphan receptor GPR39, which signals to the Gli transcription factors and blocks signaling; a useful chemical tool for in vitro interrogation of GPR39 signaling in different cellular contexts.
References	References 1. Bassilana F, et al. Nat Chem Biol. 2014 May;10(5):343-9. View Related Products by Target GPR39