1558598-41-6
1558598-41-6 structure
- Name: PFM 01
- Chemical Name: PFM01
- CAS Number: 1558598-41-6
- Molecular Formula: C14H15NO2S2
- Molecular Weight: 293.404
- Catalog: Signaling Pathways Others Others
- Create Date: 2020-01-11 18:06:33
- Modify Date: 2024-04-05 15:59:08
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PFM01 (SML1735) is a small molecule that specifically inhibits endonuclease, but not exonuclease activity of MRE11, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM, blocks the ssDNA-binding path toward the catalytic metal ions and disrupts endonuclease activity.
| Name | PFM01 |
|---|---|
| Synonyms |
PFM01
4-Thiazolidinone, 5-[(4-hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-, (5Z)- 5-(4-Hydroxybenzylidene)-3-isobutyl-2-thioxothiazolidin-4-one 5-(4-Hydroxy-benzylidene)-3-isobutyl-2-thioxo-thiazolidin-4-one (5Z)-5-(4-Hydroxybenzylidene)-3-isobutyl-2-thioxo-1,3-thiazolidin-4-one (5Z)-5-[(4-Hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-4-thiazolidinone MFCD02220972 |
| Description | PFM01 (SML1735) is a small molecule that specifically inhibits endonuclease, but not exonuclease activity of MRE11, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM, blocks the ssDNA-binding path toward the catalytic metal ions and disrupts endonuclease activity. |
|---|---|
| References | References 1. Shibata A, et al. Mol Cell. 2014 Jan 9;53(1):7-18. 2. Hengel SR, et al. Cell Chem Biol. 2017 Sep 21;24(9):1101-1119. View Related Products by Target DNA Repair Protein |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 435.2±55.0 °C at 760 mmHg |
| Molecular Formula | C14H15NO2S2 |
| Molecular Weight | 293.404 |
| Flash Point | 217.0±31.5 °C |
| Exact Mass | 293.054413 |
| LogP | 2.74 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.684 |
| Storage condition | 2-8°C |
| Hazard Codes | Xi |
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