2219320-08-6

2219320-08-6 structure

Name: MSC 1094308
Chemical Name: MSC1094308
CAS Number: 2219320-08-6
Molecular Formula: C₂₉H₂₉F₃N₂
Molecular Weight: 462.55
Catalog: Signaling Pathways Cell Cycle/DNA Damage p97
Create Date: 2019-10-09 12:40:29
Modify Date: 2025-08-27 13:25:58
MSC1094308 is a reversible and allosteric inhibitor of the type II AAA ATPase human ubiquitin-directed unfoldase (VCP)/p97 and the type I AAA ATPase VPS4B, with IC50 values of 0.71 μM and 7.2 μM for VPS4B and p97, respectively[1].

Name	MSC1094308
Synonyms	MFCD31814427

Description	MSC1094308 is a reversible and allosteric inhibitor of the type II AAA ATPase human ubiquitin-directed unfoldase (VCP)/p97 and the type I AAA ATPase VPS4B, with IC50 values of 0.71 μM and 7.2 μM for VPS4B and p97, respectively[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> p97 Research Areas >> Others
Target	IC50: 0.71 μM (VPS4B), 7.2 μM (p97)[1].
References	[1]. Pöhler R, et al. A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases. Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1576-1580.

Hazard Codes	Xi