1357248-83-9

1357248-83-9 structure

Name: LIN28 inhibitor LI71
Chemical Name: LIN28 inhibitor LI71
CAS Number: 1357248-83-9
Molecular Formula: C₂₁H₂₁NO₃
Molecular Weight: 335.40
Catalog: Signaling Pathways Epigenetics MicroRNA
Create Date: 2019-09-09 08:39:51
Modify Date: 2025-08-25 08:19:53
LIN28 inhibitor LI71 is a potent and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM. LIN28 inhibitor LI71 directly binds the cold shock domain (CSD) to suppress LIN28’s activity against let-7 in leukemia cells and embryonic stem cells[1].

Name	LIN28 inhibitor LI71

Description	LIN28 inhibitor LI71 is a potent and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM. LIN28 inhibitor LI71 directly binds the cold shock domain (CSD) to suppress LIN28’s activity against let-7 in leukemia cells and embryonic stem cells[1].
Related Catalog	Signaling Pathways >> Epigenetics >> MicroRNA Research Areas >> Others
Target	IC50: 7 uM (LIN28)[1]
References	[1]. Wang L, et al. Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28. Cell Rep. 2018 Jun 5;23(10):3091-3101.

Molecular Formula	C₂₁H₂₁NO₃
Molecular Weight	335.40

Hazard Codes	Xi