1941211-99-9

1941211-99-9 structure

Name: LSN 3213128
Chemical Name: LSN 3213128
CAS Number: 1941211-99-9
Molecular Formula: C₁₇H₁₆FN₃O₄S₂
Molecular Weight: 409.46
Catalog: Signaling Pathways Cell Cycle/DNA Damage Antifolate
Create Date: 2019-08-03 16:47:58
Modify Date: 2024-01-08 07:51:34
LSN 3213128 is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), with IC50 of 16 nM for AICARFT enzyme inhibiton and 19 nM in cells. Anti-tumor activity[1].

Name	LSN 3213128

Description	LSN 3213128 is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), with IC50 of 16 nM for AICARFT enzyme inhibiton and 19 nM in cells. Anti-tumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Antifolate
Target	IC50: 16 nM (AICARFT), 19 nM (AICARFT in cells)[1]
References	[1]. Fales KR, et al. Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model. J Med Chem. 2017 Dec 14;60(23):9599-9616.

Molecular Formula	C₁₇H₁₆FN₃O₄S₂
Molecular Weight	409.46