145821-57-4

145821-57-4 structure

Name: Tiagabine hydrochloride hydrate
Chemical Name: Tiagabine hydrochloride hydrate
CAS Number: 145821-57-4
Molecular Formula: C₂₀H₂₈ClNO₃S₂
Molecular Weight: 430.02
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2019-06-29 18:22:05
Modify Date: 2025-08-27 05:05:45
Tiagabine hydrochloride hydrate is a potent and selective GABA uptake inhibitor, used as an anticonvulsant agent, with IC50s of 67, 446 and 182 nM for [3H]GABA uptake in Synaptosomes, Neurons and Glia, respectively[1].

Name	Tiagabine hydrochloride hydrate

Description	Tiagabine hydrochloride hydrate is a potent and selective GABA uptake inhibitor, used as an anticonvulsant agent, with IC50s of 67, 446 and 182 nM for [3H]GABA uptake in Synaptosomes, Neurons and Glia, respectively[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
References	[1]. Braestrup C, et al. (R)-N-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]nipecotic acid binds with high affinity to the brain gamma-aminobutyric acid uptake carrier. J Neurochem. 1990 Feb;54(2):639-47.

RIDADR	NONH for all modes of transport