1231930-57-6

1231930-57-6 structure

1231930-57-6 structure

Name: Abemaciclib Metabolites M2
Chemical Name: Abemaciclib Metabolites M2
CAS Number: 1231930-57-6
Molecular Formula: C₂₅H₂₈F₂N₈
Molecular Weight: 478.54
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2019-06-30 11:20:15
Modify Date: 2024-01-14 10:03:39
Abemaciclib Metabolites M2 is a metabolite of abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s in the range of 1-3 nM. Anti-cancer activity[1].

Name	Abemaciclib Metabolites M2

Description	Abemaciclib Metabolites M2 is a metabolite of abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s in the range of 1-3 nM. Anti-cancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	CDK4:1-3 nM (IC50) CDK6:1-3 nM (IC50)
References	[1]. Teresa Burke, et al. Abstract 2830: The major human metabolites of abemaciclib are inhibitors of CDK4 and CDK6. Cancer Research. July 2016, 76 (14).

Molecular Formula	C₂₅H₂₈F₂N₈
Molecular Weight	478.54