Abemaciclib Metabolites M2

Modify Date: 2025-08-26 18:02:31

Abemaciclib Metabolites M2 structure	Common Name	Abemaciclib Metabolites M2
	CAS Number	1231930-57-6	Molecular Weight	478.54
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₈F₂N₈	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Abemaciclib Metabolites M2

Abemaciclib Metabolites M2 is a metabolite of abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s in the range of 1-3 nM. Anti-cancer activity[1].

Name	Abemaciclib Metabolites M2

Description	Abemaciclib Metabolites M2 is a metabolite of abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s in the range of 1-3 nM. Anti-cancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	CDK4:1-3 nM (IC50) CDK6:1-3 nM (IC50)
References	[1]. Teresa Burke, et al. Abstract 2830: The major human metabolites of abemaciclib are inhibitors of CDK4 and CDK6. Cancer Research. July 2016, 76 (14).

Molecular Formula	C₂₅H₂₈F₂N₈
Molecular Weight	478.54
InChIKey	IXGZDCRFGCEEBU-UHFFFAOYSA-N
SMILES	Cc1nc2c(F)cc(-c3nc(Nc4ccc(CN5CCNCC5)cn4)ncc3F)cc2n1C(C)C

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