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328565-16-8

328565-16-8 structure
328565-16-8 structure
  • Name: Col 003
  • Chemical Name: Col003
  • CAS Number: 328565-16-8
  • Molecular Formula: C14H11NO4
  • Molecular Weight: 257.24
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage HSP
  • Create Date: 2019-06-01 14:34:56
  • Modify Date: 2025-08-27 15:53:29
  • Col003 is a potent inhibitor of Hsp47, competitively binds to the collagen binding site on Hsp47 (IC50, 1.8 μM), and inhibits collagen secretion by destabilizing the collagen triple helix[1].

Name Col003
Description Col003 is a potent inhibitor of Hsp47, competitively binds to the collagen binding site on Hsp47 (IC50, 1.8 μM), and inhibits collagen secretion by destabilizing the collagen triple helix[1].
Related Catalog
Target

HSP47:1.8 μM (IC50)

References

[1]. Ito S, et al. A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis. J Biol Chem. 2017 Dec 8;292(49):20076-20085.

Molecular Formula C14H11NO4
Molecular Weight 257.24
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