1800070-77-2
1800070-77-2 structure
- Name: Borussertib
- Chemical Name: Borussertib
- CAS Number: 1800070-77-2
- Molecular Formula: C36H32N6O3
- Molecular Weight: 596.68
- Catalog: Signaling Pathways PI3K/Akt/mTOR Akt
- Create Date: 2019-06-01 15:36:56
- Modify Date: 2024-01-03 17:40:13
-
Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt[1].
| Name | Borussertib |
|---|
| Description | Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt[1]. |
|---|---|
| Related Catalog | |
| Target |
Aktwt:0.8 nM (IC50) Aktwt:2.2 nM (Ki) |
| In Vitro | Borussertib exhibits excellent cellular activity in the nanomolar range with superior profile against clinical candidate Akt inhibitors as well as the cytostatic drug doxorubicin. The EC50 values are 191±90 nM, 48±15 nM, 5±1 nM, 277±90 nM, 373±54 nM, 7770±641 nM in AN3CA (endometrium), T47D (breast), ZR-75-1 (breast), MCF-7 (breast), BT-474 (breast) and KU-19-19 (bladder) cell lines, respectively[1]. |
| References |
| Molecular Formula | C36H32N6O3 |
|---|---|
| Molecular Weight | 596.68 |