Borussertib
Modify Date: 2024-01-03 17:40:13
Borussertib structure
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Common Name | Borussertib | ||
|---|---|---|---|---|
| CAS Number | 1800070-77-2 | Molecular Weight | 596.68 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C36H32N6O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BorussertibBorussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt[1]. |
| Name | Borussertib |
|---|
| Description | Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt[1]. |
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| Related Catalog | |
| Target |
Aktwt:0.8 nM (IC50) Aktwt:2.2 nM (Ki) |
| In Vitro | Borussertib exhibits excellent cellular activity in the nanomolar range with superior profile against clinical candidate Akt inhibitors as well as the cytostatic drug doxorubicin. The EC50 values are 191±90 nM, 48±15 nM, 5±1 nM, 277±90 nM, 373±54 nM, 7770±641 nM in AN3CA (endometrium), T47D (breast), ZR-75-1 (breast), MCF-7 (breast), BT-474 (breast) and KU-19-19 (bladder) cell lines, respectively[1]. |
| References |
| Molecular Formula | C36H32N6O3 |
|---|---|
| Molecular Weight | 596.68 |