848217-00-5

848217-00-5 structure

Name: H4 Receptor antagonist 1
Chemical Name: H4 Receptor antagonist 1
CAS Number: 848217-00-5
Molecular Formula: C₁₆H₁₇ClN₄O
Molecular Weight: 316.79
Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
Create Date: 2019-02-08 18:50:04
Modify Date: 2025-08-24 16:59:48
H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC50 of 19 nM.

Name	H4 Receptor antagonist 1

Description	H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC50 of 19 nM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Neurological Disease
Target	H4 receptor:19 nM (IC50)
In Vitro	H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC50 of 19 nM[1].
In Vivo	H4 Receptor antagonist 1 indicates that metabolic stability in rat microsomes is very low with only 1% parent compound remaining after 10 min incubation[1].
References	[1]. Cramp S, et al. Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2516-9.