Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Closthioamide
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Purity: 98.0%
Stocking Period: 10 Day
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1227367-59-0

1227367-59-0 structure

1227367-59-0 structure

Name: Closthioamide
Chemical Name: Closthioamide
CAS Number: 1227367-59-0
Molecular Formula: C₂₉H₃₈N₆O₂S₆
Molecular Weight: 695.041
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-09-01 05:51:59
Modify Date: 2024-04-08 00:44:23
Closthioamide is a potent inhibitor of bacterial DNA gyrase and highly active against Ec, MRSA, VRE and Mv), with MICs of 9.00 μM, 0.58 μM, 0.58 μM and 72.03 μM respectively.

Name	Closthioamide
Synonyms	Benzenecarbothioamide, N,N'-(3,7,13,17-tetrathioxo-4,8,12,16-tetraazanonadecane-1,19-diyl)bis[4-hydroxy- N,N'-(3,7,13,17-Tetrathioxo-4,8,12,16-tetraazanonadecane-1,19-diyl)bis(4-hydroxybenzenecarbothioamide)

Description	Closthioamide is a potent inhibitor of bacterial DNA gyrase and highly active against Ec, MRSA, VRE and Mv), with MICs of 9.00 μM, 0.58 μM, 0.58 μM and 72.03 μM respectively.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection Natural Products >> Others
Target	Bacterial DNA gyrase[1]. MIC: 9.00 μM (Ec), 0.58 μM (MRSA), 0.58 μM (VRE), 72.03 μM (Mv)[2].
In Vitro	Closthioamide is a potent inhibitor of bacterial DNA gyrase, isolated from the strictly anaerobic banterium Clostridium cellulolyticum and belongs to a new class of natural products[1]. In a standardized antimicrobial assay, it is found that closthioamide is highly active against a pathogenic, methicillin-resistant Staphylococcus aureus (MRSA) strain with a minimum inhibitory concentration (MIC) of 0.4 μg/mL-1 (0.58 μM). Closthioamide is even active against vancomycin-resistant Enterococcus faecalis (VRE) with the same low MIC value, and is thus significantly more potent against these bacteria than ciprofloxacin, the standard drugused against VRE, with remarkable strain selectivity. Furthermore, in a standardized cytotoxicity assay, closthioamide shows moderate antiproliferative and cytotoxic effects[2].
Cell Assay	The MIC is determined for the laboratory strains as follows. The assays are performed in sterile 96-well polystyrene microplates in 200 mL of cation-adjusted Mueller-Hinton (MH) broth. A serial dilution of the compound to test is made in 100 mL of medium and inoculated with 100 mL of fresh cell culture containing ~105 cfu/mL and incubated at 37°C for 20 h. The MIC is defined as the lowest concentration of antibiotic that inhibit visible growth[1].
References	[1]. Chiriac AI, et al. Mode of action of closthioamide: the first member of the polythioamide class of bacterial DNA gyrase inhibitors. J AntimicrobChemother. 2015Sep;70(9):2576-88. [2]. Lincke T, et al. Closthioamide: an unprecedented polythioamide antibiotic from the strictly anaerobic bacterium Clostridium cellulolyticum.Angew Chem Int Ed Engl. 2010 Mar 8;49(11):2011-3.

Density	1.4±0.1 g/cm3
Boiling Point	857.0±75.0 °C at 760 mmHg
Molecular Formula	C₂₉H₃₈N₆O₂S₆
Molecular Weight	695.041
Flash Point	472.1±37.1 °C
Exact Mass	694.138062
LogP	5.27
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.706

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