166527-00-0

166527-00-0 structure

Name: 7-Desmethyl-3-hydroxyagomelatine
Chemical Name: 7-DesMethyl-3-hydroxyagoMelatine
CAS Number: 166527-00-0
Molecular Formula: C₁₄H₁₅NO₃
Molecular Weight: 245.2738
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2018-10-17 12:00:57
Modify Date: 2024-01-14 19:21:34
7-Desmethyl-3-hydroxyagomelatine (3-Hydroxy-7-desmethyl agomelatine), a metabolite of Agomelatine, has less activity than Agomelatine[1]. Agomelatine is a melatonergic (MT1 and MT2) agonist and serotonergic (5HT2C) antagonist[1][2].

Name	7-DesMethyl-3-hydroxyagoMelatine

Description	7-Desmethyl-3-hydroxyagomelatine (3-Hydroxy-7-desmethyl agomelatine), a metabolite of Agomelatine, has less activity than Agomelatine[1]. Agomelatine is a melatonergic (MT1 and MT2) agonist and serotonergic (5HT2C) antagonist[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Melatonin Receptor Signaling Pathways >> GPCR/G Protein >> Melatonin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	MT1 MT2 5-HT2C Receptor
References	[1]. Li M, et al. Development and validation a LC-MS/MS method for the simultaneous determination of agomelatine and its metabolites, 7-desmethyl-agomelatine and 3-hydroxy-agomelatine in human plasma: Application to a bioequivalence study. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 15;1003:60-6. [2]. Kennedy SH, et al. Agomelatine and its therapeutic potential in the depressed patient. Neuropsychiatr Dis Treat. 2007 Aug;3(4):423-8.

Molecular Formula	C₁₄H₁₅NO₃
Molecular Weight	245.2738