1174664-88-0
1174664-88-0 structure
- Name: VER-00158411
- Chemical Name: 1174664-88-0
- CAS Number: 1174664-88-0
- Molecular Formula:
- Molecular Weight:
- Catalog: Research Areas Cancer
- Create Date: 2018-06-20 20:45:03
- Modify Date: 2023-01-21 09:54:46
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VER-00158411 is a checkpoint kinase 1 (CHK1) and CHK2 inhibitor with IC50 values of 4.4 nM and 4.5 nM, respectively[1].
| Name | 1174664-88-0 |
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| Description | VER-00158411 is a checkpoint kinase 1 (CHK1) and CHK2 inhibitor with IC50 values of 4.4 nM and 4.5 nM, respectively[1]. |
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| Related Catalog | |
| Target |
Chk1:4.4 nM (IC50) Chk2:4.5 nM (IC50) |
| In Vitro | Cellular sensing of DNA damage, along with concomitant cell cycle arrest, is mediated by a great many proteins and enzymes. One focus of pharmaceutical development has been the inhibition of DNA damage signaling, and checkpoint kinases (CHKs). There have been a number of clinical trial of checkpoint kinase inhibits alone or as a combination therapy for example, as a means to sensitize proliferating tumor cells to chemotherapies that damage DNA. The development of checkpoint kinase inhibitors the treatment of cancer was a major objective in drug discovery[1]. |
| References |
[1]. Ann Gee Lisa OOI, et al. Combination therapy. 26 July 2018. WO2018136010A1 |
| No Any Chemical & Physical Properties |