VER-00158411
Modify Date: 2025-09-24 17:43:34
VER-00158411 structure
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Common Name | VER-00158411 | ||
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| CAS Number | 1174664-88-0 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | N/A | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of VER-00158411VER-00158411 is a checkpoint kinase 1 (CHK1) and CHK2 inhibitor with IC50 values of 4.4 nM and 4.5 nM, respectively[1]. |
| Name | 1174664-88-0 |
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| Description | VER-00158411 is a checkpoint kinase 1 (CHK1) and CHK2 inhibitor with IC50 values of 4.4 nM and 4.5 nM, respectively[1]. |
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| Related Catalog | |
| Target |
Chk1:4.4 nM (IC50) Chk2:4.5 nM (IC50) |
| In Vitro | Cellular sensing of DNA damage, along with concomitant cell cycle arrest, is mediated by a great many proteins and enzymes. One focus of pharmaceutical development has been the inhibition of DNA damage signaling, and checkpoint kinases (CHKs). There have been a number of clinical trial of checkpoint kinase inhibits alone or as a combination therapy for example, as a means to sensitize proliferating tumor cells to chemotherapies that damage DNA. The development of checkpoint kinase inhibitors the treatment of cancer was a major objective in drug discovery[1]. |
| References |
[1]. Ann Gee Lisa OOI, et al. Combination therapy. 26 July 2018. WO2018136010A1 |
| InChIKey | REQMZUHAMVOEON-UHFFFAOYSA-N |
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| SMILES | CN(C)CC(C)(C)COc1ccc2[nH]c(-c3cc(NC(=O)c4cnn(Cc5ccccc5)c4)c[nH]c3=O)cc2c1 |