1151668-24-4
1151668-24-4 structure
- Name: BNS-22
- Chemical Name: 8-(3,4-Dihydro-1(2H)-quinolinylcarbonyl)-5,7-dimethoxy-4-propyl-2H-chromen-2-one
- CAS Number: 1151668-24-4
- Molecular Formula: C24H25NO5
- Molecular Weight: 407.459
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
- Create Date: 2018-07-06 07:48:48
- Modify Date: 2025-08-24 21:55:09
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BNS-22 is a DNA topoisomerase II (TOP2) catalytic inhibitor with the IC50 values of 2.8 μM and 0.42 μM for human TOP2α and TOP2β, respectively. BNS-22 induces abnormal division and has anti-proliferative activity[1].
| Name | 8-(3,4-Dihydro-1(2H)-quinolinylcarbonyl)-5,7-dimethoxy-4-propyl-2H-chromen-2-one |
|---|---|
| Synonyms |
MFCD22628799
2H-1-Benzopyran-2-one, 8-[(3,4-dihydro-1(2H)-quinolinyl)carbonyl]-5,7-dimethoxy-4-propyl- 8-(3,4-Dihydro-1(2H)-quinolinylcarbonyl)-5,7-dimethoxy-4-propyl-2H-chromen-2-one |
| Description | BNS-22 is a DNA topoisomerase II (TOP2) catalytic inhibitor with the IC50 values of 2.8 μM and 0.42 μM for human TOP2α and TOP2β, respectively. BNS-22 induces abnormal division and has anti-proliferative activity[1]. |
|---|---|
| Related Catalog | |
| Target |
topoisomerase II alpha:2.8 μM (IC50, in human) topoisomerase II beta:0.42 μM (IC50, in human) |
| In Vitro | BNS-22 (0-30 μM, 24-48 h) can inhibit cell growth and influence on cell cycle progression of the human cervical epidermoid carcinoma cell line HeLa in a dose-dependent manner[1]. BNS-22 (0-30 μM, 0-6 h) does not induce DNA damage and has an antagonistic effect on TOP2 toxin-mediated DNA damage[1]. Cell Proliferation Assay[1] Cell Line: HeLa cell lines Concentration: 0-30 μM Incubation Time: 24 h, 48 h Result: Inhibited cell growth with the IC50 value of 4.9 μM after 24 hours and 1.0 μM after 48 hours. Cell Cycle Analysis[1] Cell Line: HeLa cell lines Concentration: 0-30 μM Incubation Time: 24 h Result: Increased number of cells in G2/M phase. Disrupted mitotic spindle formation and induced polyploid cell formation at 3 μM. Western Blot Analysis[1] Cell Line: HeLa cell lines Concentration: 0-30 μM Incubation Time: 0, 30 min, 1 h, 2 h, 4 h, 6 h Result: Decreased etoposide-induced γ-H2AX expression and decreased total cellular TOP2β levels, but not TOP2α levels. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 622.7±55.0 °C at 760 mmHg |
| Molecular Formula | C24H25NO5 |
| Molecular Weight | 407.459 |
| Flash Point | 330.4±31.5 °C |
| Exact Mass | 407.173279 |
| LogP | 4.10 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.593 |
