145199-73-1
145199-73-1 structure
- Name: Kaliotoxin
- Chemical Name: Kaliotoxin
- CAS Number: 145199-73-1
- Molecular Formula: C171H282N55O49S8
- Molecular Weight:
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
- Create Date: 2018-06-26 23:31:49
- Modify Date: 2024-01-10 09:43:19
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Kaliotoxin is a peptidyl inhibitor of neuronal BK-Type. Kaliotoxin can specific inhibit Kv channels and calcium-activated potassium channels. Kaliotoxin can be used for the research of the regulation of membrane potential and neuron excitability[1][2].
| Name | Kaliotoxin |
|---|
| Description | Kaliotoxin is a peptidyl inhibitor of neuronal BK-Type. Kaliotoxin can specific inhibit Kv channels and calcium-activated potassium channels. Kaliotoxin can be used for the research of the regulation of membrane potential and neuron excitability[1][2]. |
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| Related Catalog | |
| Target |
Kd: 20 nM (KCa channel)[1] |
| In Vitro | Kaliotoxin (KTX) (250 nM) specifically suppressed the whole cell Ca2+-activated K+ current[1]. Kaliotoxin interacts in a one-to-one way with KCa channels with a Kd of 20 nM[1]. |
| In Vivo | Kaliotoxin facilitates cognitive processes by the blockage of Kv1.1 or Kv1.3 channels[2]. Animal Model: Male Sprague–Dawley rats (280–300 g)[2] Dosage: 10 ng Administration: Intracerebroventricular injection Result: Improved learning but not information consolidation. Increased the long-term retrieval of an odour-reward association. |
| Molecular Formula | C171H282N55O49S8 |
|---|